Hwang Woo Suk (1952~)
Unfortunately, many Koreans including I associate stem cells, the greatest asset of modern science, with one of the most scandalous incidents of fraud in human history. A sequence of revelations and the ensuing national delirium has showed how science, when combined with blind nationalism and dirty political calculations, can push one nation into an abyss of irrationality.
It was 2004 when Hwang, a professor/researcher of Seoul National University, announced that his team was successful in culturing an embryonic stem cell from a cloned human somatic cell. This seemingly groundbreaking achievement, outlined in a 9 page paper published in <Science> (http://www.sciencemag.org/content/303/5664/1669.full.pdf), gave Hwang a literally untouchable reputation as a national hero. Hwang's method of creating an embyonic stem cell was a classical one that extracts the embryo from a zygote (This means that Hwang's method, regardless of the all scandals and scams involved, was to soon become outdated whatsoever, along with the discovery of the innovative iPSC method.) Awed by this seemingly unforeseen technology and the new possibilities sprouting from it, Koreans lavished almost unconditional support to this powerful figure. There were even talks about adding his success story in middle school textbook. That pretty much explains itself.
In 2005, a group of young scientists in an online community named BRIC raised questions about the pictures used in Hwang's 2004 paper. Apparently the pictures used in Hwang's paper were all identical, merely a set of photos taken in different angles. As the doubt rapidly spread online, Hwang's team promptly announced that everything was a minor 'mistake', and claimed that they have already informed <Science> about this error. These excuses later on turned out to be flagrant lies. The entire nation was divided into two. Many politicians and mass media zealously defended Hwang, condemning the doubters as traitors to the nation. Many scientists and experts who either questioned or criticized Hwang were often blackmailed by his advocates. Engulfing the country was Fascist madness that, no matter what Hwang has done, every Korean should all support this hopless fraud and cheat. Eventually after a sequence of honest testimonies given by many courageous whistle-blowers, Hwang was virtually ostracized from the Korean scientific community.
This shameful incident was literally an atomic bomb dropped on Korean society. Perhaps the ugliest aspects of Korea were revealed to the world--moral hazard of scientists who refused to seek the truth, corrupted politicians who advocated Hwang for political purposes, incompetence of the government to resolve the situation, academia's negligence in scientific verification, and above all, the Korean people's tendency of extreme nationalism. We have seen through this incident how the interference of nationalism in science can cause unimaginably detrimental consequences. Science should always exist as science. "Science knows no country, because knowledge belongs to humanity, and is the torch which illuminates the world." (Pasteur).
2014년 1월 28일 화요일
2014년 1월 24일 금요일
Stem Cell 101
1. The type of stem cell which the article mainly discusses is the embryonic stem cell. Sperm and egg undergo fertilization form a zygote. A zygote then divides into many cells through cell division, and these cells form what's called embryos after division and differentiation. It is after differentiation that each embryo acquires a specific function, only able to form certain cell types such as muscle or bone. The scientific principle behind stem cells is that this embryo, once not having underwent differentiation, is capable of becoming any of the 220 cell types in the human body. By extracting those 'pluripotent' embryos and growing them seperately, we are able to obtain the embryonic stem cells which can be used to regenerate damaged tissues and organisms.
Another type of stem cell, perhaps the more orthodox and uncontroversial among the two, is the adult stem cell. Adult stem cells are yet undifferentiated cells that are capable of differentiating into specific organisms if necessary. Unlike embryonic stem cells, adult stem cells inherently exist in the human body (usually in the marrows) in extremely small amounts, and are incapable of forming all cell types with no limitations. One renowned example of an adult stem cell existing in our bodies is the Hematopoietic Stem Cell, widely used in bone-marrow transplantation among leukemia patients.
The newly developed iPCS perhaps epitomizes the cutting edge stem cell technology of the era--iPCS, first found by Prof. Yamanaka of Kyoto University, refers to the specially manipulated somatic cells that are literally 'reprogrammed' to function as differentiable embryonic cells. Enabling such is the transplantation of embryonic genes into the somatic cells through the use of retroviruses, the 'carriers' of the genes. The efficiency of iPCS method is an absolutely unparalleled one, for conventional methods of reprogramming involed an extremely elaborate process by which the genetic material from an adult cell is injected into an egg cell whose DNA has been removed.
2. Though it requires great precision, cloning, in its essence, is an extremely straightforward process. First you remove the nucleus from the fertilized egg, and replace the removed nucleus with a nucleus obtained from a cell of another living organism. Since the DNA information of the egg would then also be replaced with that of the nucleus donor, the offspring generated afterwards would be the exactly identical 'clone' of the donor.
3. The ethical question regarding stem cells is whether we should view the embryo as a seperate, independent living organism. The embryo itself is often destroyed when its pluripotent portion is extracted and seperated. Many Christians (mainly the Catholics) have spearheaded the anti-embryonic stem cell movement for they view an embryo as a basic form of life with spirit, and therefore believe that the destruction of such embryo is equivalent to murder. However, as the innovate iPCS method has rised, many of the ethical controversies about stem cells have generally diminished.
+Egg donor problem; black market? --also solved thanks to iPCS
Another type of stem cell, perhaps the more orthodox and uncontroversial among the two, is the adult stem cell. Adult stem cells are yet undifferentiated cells that are capable of differentiating into specific organisms if necessary. Unlike embryonic stem cells, adult stem cells inherently exist in the human body (usually in the marrows) in extremely small amounts, and are incapable of forming all cell types with no limitations. One renowned example of an adult stem cell existing in our bodies is the Hematopoietic Stem Cell, widely used in bone-marrow transplantation among leukemia patients.
The newly developed iPCS perhaps epitomizes the cutting edge stem cell technology of the era--iPCS, first found by Prof. Yamanaka of Kyoto University, refers to the specially manipulated somatic cells that are literally 'reprogrammed' to function as differentiable embryonic cells. Enabling such is the transplantation of embryonic genes into the somatic cells through the use of retroviruses, the 'carriers' of the genes. The efficiency of iPCS method is an absolutely unparalleled one, for conventional methods of reprogramming involed an extremely elaborate process by which the genetic material from an adult cell is injected into an egg cell whose DNA has been removed.
2. Though it requires great precision, cloning, in its essence, is an extremely straightforward process. First you remove the nucleus from the fertilized egg, and replace the removed nucleus with a nucleus obtained from a cell of another living organism. Since the DNA information of the egg would then also be replaced with that of the nucleus donor, the offspring generated afterwards would be the exactly identical 'clone' of the donor.
3. The ethical question regarding stem cells is whether we should view the embryo as a seperate, independent living organism. The embryo itself is often destroyed when its pluripotent portion is extracted and seperated. Many Christians (mainly the Catholics) have spearheaded the anti-embryonic stem cell movement for they view an embryo as a basic form of life with spirit, and therefore believe that the destruction of such embryo is equivalent to murder. However, as the innovate iPCS method has rised, many of the ethical controversies about stem cells have generally diminished.
+Egg donor problem; black market? --also solved thanks to iPCS
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